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Possible mechanisms by which Akt promotes cell survival include phosphorylation and inactivation of the proapoptotic proteins BAD and caspase-9 34.
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Akt also phosphorylates and inactivates the Forkhead transcription factors, resulting in reduced expression of the cell cycle inhibitor p27 Kip1 and the Fas ligand 5 - 7.
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Intra-abdominally disseminated tumors harvested from the different groups were processed for immunohistochemical analyses. But misfortune befalls her almost immediately, and she is captured by depraved slave traders!
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